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Multifactor analysis of the norfloxacin action on the primary immune response to the bacterial antigen (EV vaccine fraction 1) and cellular antigen (sheep erythrocytes) in mice was carried out with using a wide variety of the doses and administration times. In the doses corresponding to the average therapeutic ones norfloxacin was shown to have no effect on the humoral immune response to the bacterial and cellular antigens. In the subtherapeutic doses norfloxacin increased it thus mainly stimulating the synthesis of the IgM antibodies. In the doses exceeding the therapeutic ones the antibiotic lowered the antibody content. The diverse type immunoregulatory action of norfloxacin on the content of the IgG and IGM antibodies could be useful in the rational choice of fluoroquinolones for the treatment of patients with selective deficiency of immunoglobulins of various classes.
A I Iordanova, and
T V Smolkina, and
A V Nikitin
November 1990,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A I Iordanova, and
T V Smolkina, and
A V Nikitin
January 1982,
The Journal of rheumatology. Supplement,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
January 1981,
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A I Iordanova, and
T V Smolkina, and
A V Nikitin
September 1971,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
January 1988,
Medical microbiology and immunology,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
November 1995,
Biokhimiia (Moscow, Russia),
A I Iordanova, and
T V Smolkina, and
A V Nikitin
May 1982,
Immunology,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
January 1990,
Immunology series,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
January 1984,
Revista clinica espanola,
A I Iordanova, and
T V Smolkina, and
A V Nikitin
December 2013,
Fish & shellfish immunology,
