-transparent.png){kind=logo}
When rabbits and humans are treated with orally administered 13-cis retinoic acid, the retinoic acid and a more polar retinoid metabolite appear in tears and lacrimal gland fluid. This study tested the hypothesis that this metabolite was a retinoyl-beta-glucuronide. Lacrimal gland fluid from rabbits treated with a pharmacologic dose of 13-cis retinoic acid was analyzed. Based on chromatographic retention time, absorbance maximum, and degradation to 13-cis retinoic acid by the enzyme beta-glucuronidase, it was shown that this retinoid metabolite is 13-cis retinoyl-beta-glucuronide. The 13-cis retinoyl-beta-glucuronide was also extracted from the lacrimal gland itself. It is concluded that 13-cis retinoyl-beta-glucuronide is a major metabolite of 13-cis retinoic acid in the rabbit and that this retinoid is secreted by the lacrimal gland.
J L Ubels, and
T B Osgood
January 1994,
Life sciences,
J L Ubels, and
T B Osgood
September 1995,
Drug metabolism and disposition: the biological fate of chemicals,
J L Ubels, and
T B Osgood
March 1992,
Teratology,
J L Ubels, and
T B Osgood
May 1992,
Biochemical pharmacology,
J L Ubels, and
T B Osgood
May 1981,
Archives of biochemistry and biophysics,
J L Ubels, and
T B Osgood
January 1992,
Drug metabolism and disposition: the biological fate of chemicals,
J L Ubels, and
T B Osgood
June 1980,
Proceedings of the National Academy of Sciences of the United States of America,
J L Ubels, and
T B Osgood
January 1986,
Archives of biochemistry and biophysics,
J L Ubels, and
T B Osgood
May 1979,
Archives of dermatology,
J L Ubels, and
T B Osgood
July 2010,
The Journal of clinical and aesthetic dermatology,
