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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 2010
Victor Enciso-Mora, and
Peter Broderick, and
Yussanne Ma, and
Ruth F Jarrett, and
Henrik Hjalgrim, and
Kari Hemminki, and
Anke van den Berg, and
Bianca Olver, and
Amy Lloyd, and
Sara E Dobbins, and
Tracy Lightfoot, and
Flora E van Leeuwen, and
Asta Försti, and
Arjan Diepstra, and
Annegien Broeks, and
Jayaram Vijayakrishnan, and
Lesley Shield, and
Annette Lake, and
Dorothy Montgomery, and
Eve Roman, and
Andreas Engert, and
Elke Pogge von Strandmann, and
Katrin S Reiners, and
Ilja M Nolte, and
Karin E Smedby, and
Hans-Olov Adami, and
Nicola S Russell, and
Bengt Glimelius, and
Stephen Hamilton-Dutoit, and
Marieke de Bruin, and
Lars P Ryder, and
Daniel Molin, and
Karina Meden Sorensen, and
Ellen T Chang, and
Malcolm Taylor, and
Rosie Cooke, and
Robert Hofstra, and
Helga Westers, and
Tom van Wezel, and
Ronald van Eijk, and
Alan Ashworth, and
Klaus Rostgaard, and
Mads Melbye, and
Anthony J Swerdlow, and
Richard S Houlston
Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.
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