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Doppler ultrasound was used to study cerebral hemodynamics in the pericallosal artery of 21 newborn infants undergoing extracorporeal membrane oxygenation (ECMO) for intractable respiratory failure. Cerebral blood flow velocity waveforms were obtained pre-ECMO, after every major change in cardiopulmonary bypass flow during ECMO, and post-ECMO. The mean pulsatility index (PI) pre-ECMO was slightly higher than after decannulation, secondary to hypocarbia pre-ECMO. The PI decreased significantly at high (61 to 120 ml/min.kg) cardiopulmonary bypass flows. This was associated with an increase in mean arterial pressure, but not with changes in Hct, PaO2, or PaCO2. A negative curvilinear relationship between the amount of cardiopulmonary bypass flow and PI was found. These data suggest an increase in cerebral blood flow velocity and vasodilation of the cerebral vessels at high cardiopulmonary bypass flows, and may explain the occurrence of intracranial hemorrhage in infants undergoing ECMO.
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
March 2013,
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
September 2004,
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
February 1990,
Nederlands tijdschrift voor geneeskunde,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
May 2003,
Zhonghua yi xue za zhi,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
July 1990,
Pediatric research,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
April 2001,
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
February 1990,
Journal of paediatrics and child health,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
March 1990,
Journal of the Formosan Medical Association = Taiwan yi zhi,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
January 1995,
Wiener klinische Wochenschrift,
M van de Bor, and
F J Walther, and
E S Gangitano, and
J R Snyder
July 1989,
Investigative radiology,
