[Effect of Rhizoma Coptidis coadministration with Cortex Cinnamomi on tissue distribution of berberine in rats]. 2010

Rui Zhang, and Kaipeng Li, and Jie Yang, and Guo Huang, and Lijuan Yang, and Yujie Zhang
School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.

OBJECTIVE To investigate the tissue distribution of berberine in rats after oral administration of Rhizoma Coptidis with Cortex Cinnamomi powder. METHODS After oral administration of Rhizoma Coptidis powder and Rhizoma Coptidis with Cortex Cinnamomi powder (6:1) at the dosage of 6 g x kg(-1) and 6.6 g x kg(-1) respectively per day for 1 week, the drug concentrations in various tissues were determined by HPLC method. The variations of berberine concentrations in tissues of two treated group of rats were compared by t test using software of SAS. RESULTS With repeated administration of Rhizoma Coptidis powder, berberine distributed widely in tissues of rats and the concentrations of berberine in tissues increased, yet berberine existed mainly in liver. Berberine concentrations in all organs investigated in the group of rats treated with Rhizoma Coptidis and Cortex Cinnamomi powder showed obvious difference with those of the group of rats treated with Rhizoma Coptidis powder (P < 0.01). The berberine concentrations increased in heart, liver and kidney, while decreased in spleen and lung. CONCLUSIONS Rhizoma Coptidis coadministration with Cortex Cinnamomi can obviously change the distribution of berberine in rat organs.

UI MeSH Term Description Entries
D008297 Male Males
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D002935 Cinnamomum zeylanicum The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES. Cinnamon,Cinnamomum verum,Cinnamons
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D000089042 Coptis chinensis A plant species of the genus COPTIS and family RANUNCULACEAE. Dried rhizome (huang-lian) has been used in TRADITIONAL CHINESE MEDICINE. It contains isoquinoline ALKALOIDS (e.g., BERBERINE and coptisine). Chinese Goldthread,Huang-Lian,Chinese Goldthreads,Goldthread, Chinese,Huang Lian
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001599 Berberine An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal. Umbellatine
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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