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The preventive effect of penicillin V (pcV) in pneumococcal otitis media in the rat has been studied. The pcV was administered either before bacterial challenge (prevention group) or after challenge but before the establishing of acute purulent otitis media (AOM) (early treatment group). In both cases a fulminant infection was avoided. Thus, in the prevention group no animal developed AOM and in the early treatment group the fulminant AOM was avoided in all cases. These results give further support to the idea of using long-term treatment with an antibiotic with a narrow spectrum to avoid recurrent AOM (rAOM). Furthermore the observation that early treatment might stop the development of fulminant AOM indicates another more restrictive possibility to use antibiotic as a prophylactic measure in otitis-prone children.
A Hermansson, and
K Prellner, and
S Hellström
March 1994,
Acta oto-laryngologica,
A Hermansson, and
K Prellner, and
S Hellström
January 1950,
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A Hermansson, and
K Prellner, and
S Hellström
June 1949,
Acta oto-laryngologica,
A Hermansson, and
K Prellner, and
S Hellström
June 1997,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
A Hermansson, and
K Prellner, and
S Hellström
October 1949,
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A Hermansson, and
K Prellner, and
S Hellström
May 1949,
Concours medical,
A Hermansson, and
K Prellner, and
S Hellström
January 1946,
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A Hermansson, and
K Prellner, and
S Hellström
May 1950,
Maanedsskrift for praktisk laegegerning og social Medicin,
A Hermansson, and
K Prellner, and
S Hellström
May 1949,
The Journal of laryngology and otology,
A Hermansson, and
K Prellner, and
S Hellström
July 2001,
Current allergy and asthma reports,
