-transparent.png){kind=logo}
The question whether penicillin V (pcV) given intermittently upon signs of upper respiratory tract infections (URTI) in otitis-prone children might prevent recurrent bouts of acute purulent otitis media (AOM) is addressed. As compared with continuous long-term antibiotic treatment as prophylaxis in otitis-prone children, intermittent administration would reduce the overall consumption of antibiotics. Seventy-six otitis-prone children less than 18 months of age were included in this double-blind, randomized, placebo-controlled multicentre study. Follow-up was from January till June. One hundred and twenty-three episodes of AOM occurred. The number of AOM episodes was reduced by 50% in the children on pcV during URTI episodes as compared with those on placebo. No obvious ecological drawbacks were noted. Thus, the described mode of pcV administration seems to be a rational and safe way to reduce the number of AOM episodes in otitis-prone children.
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
April 1990,
The Journal of infectious diseases,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
May 2003,
International journal of pediatric otorhinolaryngology,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
January 1992,
The Annals of otology, rhinology & laryngology. Supplement,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
May 1984,
Pediatric annals,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
January 1981,
The Annals of otology, rhinology & laryngology. Supplement,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
January 1990,
Acta oto-laryngologica,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
November 1946,
United States naval medical bulletin,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
September 1966,
The Annals of otology, rhinology, and laryngology,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
December 2015,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
K Prellner, and
M Foglé-Hansson, and
F Jørgensen, and
O Kalm, and
C Kamme
October 2000,
Lancet (London, England),
