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In this study cytostatic and chemosensitizing actions of gestagens are described. Cytostatic mechanisms can be divided into estrogen-mediated and independent ones. The former include down-regulation of estrogen receptors, induction of 17?-hydroxysteroid dehydrogenase and estron sulfotransferase. The latter are MAP-kinase inhibition, induction of cell differentiation and apoptosis. Chemosensitization by gestagens is due to inhibition of P-glycoprotein, GST and MRP. Another putative chemosensitization mechanisms involves mitochondrial transition pore (MTP), at least for such gestagens as buterol and acetomepregenol. Elucidation of common mechanisms of MTP and MDR regulation and the possible role of MTP in chemosensitization is a new direction of investigations into the action of steroid hormones.
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
January 2006,
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T A Fedotcheva, and
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N L Shimanovskiĭ
December 1986,
Nihon Sanka Fujinka Gakkai zasshi,
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
June 1990,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
T A Fedotcheva, and
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N L Shimanovskiĭ
March 1988,
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T A Fedotcheva, and
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N L Shimanovskiĭ
July 1964,
Toko-ginecologia practica,
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
January 2006,
Eksperimental'naia i klinicheskaia farmakologiia,
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
March 1988,
British journal of clinical practice. Supplement,
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
January 2011,
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T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
January 1994,
Vitamins and hormones,
T A Fedotcheva, and
E V Odintsova, and
N L Shimanovskiĭ
January 2001,
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