BIOMAT Database Logo BIOMAT Database Logo

Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion. 1990

D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Lilly Laboratories for Clinical Research, Eli Lilly and Company, Indianapolis, IN.

Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 60 and 430 ng/ml. Protein-stimulated acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 75 and 490 ng/ml. The mean pH of basal gastric secretions was 1.6 during placebo infusion and 4.6 when the mean plasma nizatidine concentration was 575 ng/ml.

UI MeSH Term Description Entries
D008297 Male Males
D008657 Metabolic Clearance Rate Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site. Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D004044 Dietary Proteins Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS. Proteins, Dietary,Dietary Protein,Protein, Dietary
D005744 Gastric Acid Hydrochloric acid present in GASTRIC JUICE. Hydrochloric Acid, Gastric,Acids, Gastric,Acids, Gastric Hydrochloric,Gastric Acids,Gastric Hydrochloric Acid,Gastric Hydrochloric Acids,Hydrochloric Acids, Gastric
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations

Related Publications

D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Gastric venous prostaglandin concentrations during basal and stimulated acid secretion in dog.
February 1982, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Relationship between basal serum gastrin concentrations and gastric acid secretion in peptic ulcer disease.
January 1980, Scandinavian journal of gastroenterology,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Inhibition of basal and stimulated gastric acid secretion by an enkephalin analogue.
June 1982, The American journal of gastroenterology,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Inhibition of basal and insulin-stimulated gastric acid secretion by phenoxybenzamine or phentolamine.
July 1987, The Journal of pharmacy and pharmacology,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
The relationship of alprazolam dose to steady-state plasma concentrations.
February 1990, Journal of clinical psychopharmacology,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Effect of verapamil on basal and pentagastrin-stimulated gastric acid secretion.
September 1983, Clinical pharmacology and therapeutics,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Relationship between gastro-oesophageal acid reflux, basal gastro-oesophageal sphincter pressure, and gastric acid secretion.
January 1977, Scandinavian journal of gastroenterology,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Inhibition of food-stimulated gastric acid secretion by cimetidine.
March 1976, Gut,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Basal and stimulated human gastric bicarbonate secretion.
January 1987, Scandinavian journal of gastroenterology. Supplement,
D W Schneck, and J T Callaghan, and R F Bergstrom, and B D Obermeyer, and W W Offen
Somatostatin inhibition of secretagogue and forskolin-stimulated gastric acid secretion.
April 1988, The American journal of physiology,
Copied contents to your clipboard!