-transparent.png){kind=logo}
OBJECTIVE The prevalence of the antiphospholipid syndrome was determined prospectively in patients presenting with stroke and transient ischemic attacks. An attempt was made to define a subset of stroke patients at risk for this syndrome on the basis of their clinical features. METHODS Fifty-one consecutive patients with stroke and transient ischemic attacks were assessed. Tests used for the laboratory diagnosis of the antiphospholipid syndrome included four phospholipid-dependent coagulation tests for detection of the lupus anticoagulant, and two enzyme-linked immunosorbent assays for antibodies to phospholipid. RESULTS Three of 51 patients (6%, 95% confidence intervals 0% to 12.0%) had a lupus anticoagulant and the clinical features of the antiphospholipid syndrome. Seven patients had clinical features suggestive of the syndrome but negative laboratory tests. Those patients who were clinically unlikely to have this syndrome also had negative laboratory tests. CONCLUSIONS In a series of 51 unselected patients presenting with stroke and transient ischemic attacks, three had the antiphospholipid syndrome. The clinical features of this syndrome are helpful in identifying this group of patients. The role of the lupus anticoagulant in the pathogenesis of stroke remains to be defined.
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
November 1999,
American family physician,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
January 1977,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
June 1988,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
January 1981,
Upsala journal of medical sciences,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
January 1994,
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
January 1980,
Acta medica Scandinavica,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
April 1990,
Clinical cardiology,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
September 1990,
Chinese medical journal,
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
August 1998,
Internal medicine (Tokyo, Japan),
M Trimble, and
D A Bell, and
W Brien, and
V Hachinski, and
B O'Keefe, and
C McLay, and
J Black
August 2017,
Archives of medical science : AMS,
