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We have determined the complete sequence of human vinculin, a cytoskeletal protein associated with cell-cell and cell-matrix junctions. Comparison of human and chicken embryo vinculin sequences shows that both proteins contain 1066 amino acids and exhibit a high level of sequence identity (greater than 95%). The region of greatest divergence falls within three 112-amino acid repeats spanning residues 259-589. Interestingly, nematode vinculin lacks one of these central repeats. The regions of human vinculin that are N- and C-terminal to the repeats show 54% and 61% sequence identity, respectively, to nematode vinculin. Southern blots of human genomic DNA hybridized with short vinculin cDNA fragments indicate that there is a single vinculin gene. By using a panel of human-rodent somatic cell hybrids, the human vinculin gene was mapped to chromosome 10q11.2-qter.
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
August 2002,
Animal genetics,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
June 1990,
Jinrui idengaku zasshi. The Japanese journal of human genetics,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
June 1994,
Biochemistry,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
November 1988,
Journal of steroid biochemistry,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
June 1992,
Matrix (Stuttgart, Germany),
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
May 1992,
Genomics,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
July 1987,
Biochemistry,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
May 1981,
Somatic cell genetics,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
July 1985,
American journal of human genetics,
P A Weller, and
E P Ogryzko, and
E B Corben, and
N I Zhidkova, and
B Patel, and
G J Price, and
N K Spurr, and
V E Koteliansky, and
D R Critchley
July 1986,
Investigative ophthalmology & visual science,
