BIOMAT Database Logo BIOMAT Database Logo

Prostaglandins: PGF2 alpha, PGE2, 6-keto-PGF1 alpha and TXB2 serum levels in dysmenorrheic adolescents before, during and after treatment with oral contraceptives. 1990

G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
1st Department of Obstetrics and Gynecology 'Alexandra' Maternity, University of Athens, Greece.

Ten adolescents with primary dysmenorrhea (PD) were treated with the oral contraceptive (OC) Lyndiol 2.5 mg (R) for one cycle. The levels of PGF2 alpha, PGE2 and the metabolites of PGI2 and TXA2: 6-keto-PGF1 alpha and TXB2 were tested by a radioimmunoassay method during the 1st and 23rd day of the pre-treatment cycle (PrTC), the 23rd day of treatment (TC) and the 1st day of the post-treatment cycle (PoTC). The ratios PGF2 alpha/PGE2 and TXB2/6-keto-PGF1 alpha were also tested and compared during the above-mentioned days. Analytical comparison was made, for each Prostaglandin (PG) separately, between the 1st day of the PrTC and PoTC as well as the 23rd day of the PrTC and TC, respectively. All PG levels during TC and PoTC were found significantly lower, compared to those of the PrTC respectively. With regard to the ratios mentioned above, no statistically significant differences were found on the same days and cycles as previously stated. The reduction of the PG levels in PD patients after treatment with oral contraceptives, together with an improvement of the clinical findings of the disease, support the theory that oral contraceptives can be used for the treatment of PD cases, especially for those adolescents who also desire a contraceptive method.

UI MeSH Term Description Entries
D008234 Lynestrenol A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL). 19-Norpregn-4-en-20-yn-17-ol, (17alpha)-,Ethinylestrenol,Exluton,Linesterol,Linestrenol,Lynestrenol, (9 beta, 10 alpha,17 alpha)-Isomer,Lynoestrenol
D008656 Mestranol The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES. 19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17alpha)-,Ethinyl Estradiol 3-Methyl Ether,Ethinyl Estradiol 3 Methyl Ether
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011453 Prostaglandins A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes. Prostaglandin,Prostanoid,Prostanoids
D011464 Epoprostenol A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). Prostacyclin,Prostaglandin I2,Epoprostanol,Epoprostenol Sodium,Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer,Flolan,Prostaglandin I(2),Veletri
D003277 Contraceptives, Oral, Combined Fixed drug combinations administered orally for contraceptive purposes. Combined Oral Contraceptive,Contraceptive Agents, Female, Combined,Oral Contraceptives, Combined,Combined Oral Contraceptives,Contraceptive, Combined Oral,Contraceptives, Combined Oral,Oral Contraceptive, Combined
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D004412 Dysmenorrhea Painful menstruation. Menstruation, Painful,Pain, Menstrual,Dysmenorrheas,Menstrual Pain,Menstrual Pains,Menstruations, Painful,Painful Menstruation,Painful Menstruations,Pains, Menstrual
D004997 Ethinyl Estradiol A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-,Ethynyl Estradiol,Estinyl,Ethinyl Estradiol Hemihydrate,Ethinyl Estradiol, (8 alpha)-Isomer,Ethinyl Estradiol, (8 alpha,17 alpha)-Isomer,Ethinyl Estradiol, (8 alpha,9 beta,13 alpha,14 beta)-Isomer,Ethinyl Estradiol, (9 beta,17 alpha)-Isomer,Ethinyl-Oestradiol Effik,Ethinylestradiol Jenapharm,Ethinyloestradiol,Lynoral,Microfollin,Microfollin Forte,Progynon C,Estradiol, Ethinyl,Estradiol, Ethynyl,Ethinyl Oestradiol Effik,Hemihydrate, Ethinyl Estradiol,Jenapharm, Ethinylestradiol
D005260 Female Females

Related Publications

G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
PGE2, PGF2 alpha, 6-keto-PGF1 alpha, and TxB2 synthesis along the rabbit nephron.
January 1987, The American journal of physiology,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
[Plasma PGE2, TXB2 and 6-keto PGF1 alpha levels in patients with Kawasaki disease].
September 1988, Arerugi = [Allergy],
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
[Synthesis of prostaglandins (TXB2 and 6-keto-PGF1 alpha) during cardiopulmonary bypass].
February 1986, Masui. The Japanese journal of anesthesiology,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
[The influence of indapamide on 6-keto-PGF1 alpha, PGE2, and PGF2 alpha synthesis and plasma TXB2 levels in spontaneously hypertensive rats].
February 1993, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
Effect of exercise intensity on 6-keto-PGF1 alpha, TXB2, and 6-keto-PGF1 alpha/TXB2 ratios.
March 1992, Thrombosis research,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
Determination of 6-keto-PGF1 alpha, TXB2, PGF2 alpha, PGE2, PGD2 in human blood: a comparison of RIA and GC-NICI-MS.
January 1989, Progress in clinical and biological research,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
[Effects of butylphthalide on extracellular 6-keto-PGF1 alpha, TXB2 and 6-keto-PGF1 alpha/TXB2 ratio in cultured rat cortical neurons].
December 1998, Yao xue xue bao = Acta pharmaceutica Sinica,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
Circadian rhythm of PGE2, PGF2 alpha and 6-keto-PGF1 alpha urinary excretion in healthy women.
June 1983, Prostaglandins, leukotrienes, and medicine,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients.
March 1983, Prostaglandins, leukotrienes, and medicine,
G Creatsas, and E Deligeoroglou, and A Zachari, and D Loutradis, and T Papadimitriou, and K Miras, and D Aravantinos
Plasma prostaglandins: 6-keto-PGF1 alpha, TXB2 and PGE2 in juvenile-onset diabetes determined by high-pressure liquid chromatography and radio-immunoassay.
June 1986, Prostaglandins, leukotrienes, and medicine,
Copied contents to your clipboard!