-transparent.png){kind=logo}
We investigated 18 anti-HIV seropositive subjects with respect to the isolation of HIV from peripheral blood mononuclear cells (PBMC) and cellular and serologic markers for progression to AIDS. The subjects included homosexuals and recipients of blood products. Three had AIDS, an asymptomatic subject developed AIDS during the study and 14 of the remaining have remained asymptomatic. HIV was isolated from all AIDS patients and 7 asymptomatic subjects. Moreover HIV was detected significantly sooner in symptomatic patients than in asymptomatic subjects. The reductions in CD4 lymphocytes number and CD4/CD8 ratio, as well as anti-HIV core (p24, p17) antigens negativity correlated with deterioration of clinical symptoms and successful HIV isolation. The isolates from AIDS patients and from an asymptomatic subject who 9 months later developed AIDS were infective and cytotoxic to MT-4 cells, however isolates from asymptomatic subjects were not infective. These findings indicate that disease progression correlates with the appearance of variant viruses that are more infective and cytopathic.
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
June 1995,
African journal of medicine and medical sciences,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
March 1988,
Annales medico-psychologiques,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
February 1988,
British journal of haematology,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
July 1995,
Journal of clinical periodontology,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
April 1997,
Respiratory medicine,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
December 1993,
Critical reviews in oncology/hematology,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
May 2021,
Medicine,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
May 1992,
Nutrition reviews,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
November 2013,
Bone,
T Otake, and
H Mori, and
M Morimoto, and
N Ueba, and
N Kunita, and
K Sano, and
M Nakai, and
S Okubo, and
K Yasunaga, and
N Nagao
January 2002,
Neurologia (Barcelona, Spain),
