Effect of immobilized granulocyte colony-stimulating factor on hemopoietic precursors of various classes during cytostatic-induced myelosuppression. 2010

A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru

Experiments were performed on the model of cytostatic myelosuppression induced by cyclophosphamide. We compared the effect of immobilized granulocyte CSF (the preparation was created in Russia) and reference standard preparation of granulocyte CSF on the development of neutrophilic leukopenia and hemopoietic precursors of various classes. It was found that preparations of granulocyte CSF decreased the duration and degree of peripheral blood neutropenia. The granulocytopoiesis-stimulating effect was related to stimulation of multipotent hemopoietic precursors, granulocyte-erythroid-macrophage-megakaryocyte precursors, and granulocyte precursors. Induction of division and maturation of multipotent hemopoietic precursors, granulocyte-erythroid-macrophage-megakaryocyte precursors, and granulocyte precursors and recovery of cellularity of the granulocytic hemopoietic stem after administration of immobilized granulocyte CSF were observed at later terms compared to treatment with the reference preparation of granulocyte CSF.

UI MeSH Term Description Entries
D008297 Male Males
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D009503 Neutropenia A decrease in the number of NEUTROPHILS found in the blood. Neutropenias
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D006410 Hematopoiesis The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY). Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
November 2000, Bulletin of experimental biology and medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
July 2009, Bulletin of experimental biology and medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
September 1988, The New England journal of medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
January 1992, Archivum immunologiae et therapiae experimentalis,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
August 1999, Biulleten' eksperimental'noi biologii i meditsiny,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
January 2005, Bulletin of experimental biology and medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
December 1994, British journal of haematology,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
February 2011, Bulletin of experimental biology and medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
July 2011, Bulletin of experimental biology and medicine,
A M Dygai, and E G Skurikhin, and T V Andreeva, and P G Madonov, and E I Vereshagin, and D N Kinsht, and O V Pershina, and E S Khmelevskaya
May 1995, Bone marrow transplantation,
Copied contents to your clipboard!