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Amphotericin B causes suppression of bone marrow (BM) progenitor cells in vitro. Granulocyte colony stimulating factor (G-CSF) enhances the proliferation of myeloid cells. The present study defines the role of G-CSF in preventing amphotericin B-induced myelosuppression. G-CSF increased the proliferative potential of BM and protected against amphotericin B-induced myelosuppression if it was added to the medium during the early phase of exposure of BM to amphotericin B. Monoclonal antibodies to tumour necrosis factor-alpha (TNF) or interferon-gamma (IFN) inhibited the myelosuppression partially; simultaneous presence of both these antibodies completely abrogated this suppression, suggesting that both TNF alpha and IFN gamma were involved in amphotericin-induced myelosuppression. TNF- or IFN-induced suppression of BM was also inhibited by G-CSF. These data suggest that G-CSF prevents the amphotericin B-induced myelosuppression by antagonizing the suppressive effects of TNF and IFN and by enhancing the proliferative activity of BM.
B S Charak, and
E G Brown, and
A Mazumder
September 1988,
The New England journal of medicine,
B S Charak, and
E G Brown, and
A Mazumder
January 1992,
Archivum immunologiae et therapiae experimentalis,
B S Charak, and
E G Brown, and
A Mazumder
October 2013,
Archives of pharmacal research,
B S Charak, and
E G Brown, and
A Mazumder
May 1993,
Journal of the National Cancer Institute,
B S Charak, and
E G Brown, and
A Mazumder
January 2005,
Neuroscience letters,
B S Charak, and
E G Brown, and
A Mazumder
October 2014,
Biotechnic & histochemistry : official publication of the Biological Stain Commission,
B S Charak, and
E G Brown, and
A Mazumder
December 2020,
Translational lung cancer research,
B S Charak, and
E G Brown, and
A Mazumder
September 2010,
Bulletin of experimental biology and medicine,
B S Charak, and
E G Brown, and
A Mazumder
August 1990,
Archives of surgery (Chicago, Ill. : 1960),
B S Charak, and
E G Brown, and
A Mazumder
May 2009,
Toxicology letters,
