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Synthesis of 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a] pyrimidine derivatives as potential antimicrobial agents. 1990
G Auzzi, and
A Costanzo, and
F Bruni, and
M Clauser, and
G Guerrini, and
S Selleri, and
L Pecori Vettori
Dipartimento di Scienze Farmaceutiche, Università Degli Studi di Firenze, Italy.
The synthesis of some 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]-pyrimidine derivatives is performed by reacting 2-(3-amino-1,2-dihydro-5-oxo-5H-pyrazol-4-il)-1,3,4- thiadiazoles with 2,4-pentanedione, ethyl 3-oxobutyrate and diethyl ethoxymethylenemalonate. The antimicrobial activity of the synthesized compounds is reported.
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