-transparent.png){kind=logo}
Plasma and cyst fluid were obtained from patients with palpable breast cysts and analysed for androgen conjugates and oestrone sulphate content by radioimmunoassay. Concentrations of androgen conjugates in cyst fluids varied from 15.6 to 475.5 mumols/l. These levels were much greater than those in plasma (1.3-5.2 mumols/l) and there was no association between values in cyst aspirates and plasmas obtained from the same individuals. Levels of oestrone sulphate in breast cyst fluids (1.5-744.0 nmol/l) were also generally in excess of those in plasma (2.0-59.9 nmol/l) and again no relationship was evident between concentrations in cyst fluid and the circulation. Neither was there a relationship between levels of androgen conjugate and oestrone sulphate in plasma. In contrast, a highly significant correlation (P less than 0.001) was identified between the androgen conjugate and oestrone sulphate content of cyst fluids. Levels of both androgen conjugates and oestrone sulphate were also significantly different in groups of cysts subdivided according to electrolyte classification, cysts with low Na+:K+ ratios having higher steroid concentrations than those with high Na+:K+ ratios. The biological significance of the relationship between the two conjugates in cyst fluids remains unclear but it is suggested that the accumulation of these steroids involves a common mechanism.
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
January 1985,
Breast cancer research and treatment,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
July 1989,
British journal of cancer,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
November 1986,
Acta endocrinologica,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
January 1983,
The British veterinary journal,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
February 1999,
The Journal of steroid biochemistry and molecular biology,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
November 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
September 1977,
The Biochemical journal,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
May 1997,
The Journal of endocrinology,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
November 1980,
Clinical endocrinology,
W N Scott, and
R A Hawkins, and
E Killen, and
W R Miller
September 1982,
The Veterinary record,
