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The presence and functions of steroid receptors were evaluated in three human osteosarcoma cell lines (OS1 = SA OS; OS2 = HOS TE 85, and OS3 = MNNG HOS TE 85). The human breast cancer cell line MCF-7 was used as internal control for oestrogen receptors (E2R). High and low affinity sites were characterised. The high affinity sites had a similar dissociation constant in all four cell lines. In contrast, the number of sites per cell was higher in MCF-7 cells. E2 did not significantly modify the number of progesterone receptors (PgR) per cell in any of the osteosarcoma lines. As expected, E2 increased the number of PgR sites per MCF-7 cell. 4-hydroxytamoxifen decreased the growth of MCF-7 cells only. OS1 and OS2 were sensitive only to the highest concentration tested, which produces only non-specific cytotoxic effects. Thus E2R and PgR were found in osteoblast-like cells, but the function of E2R in such cells remains unknown.
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
January 1989,
Connective tissue research,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
January 1998,
The Journal of international medical research,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
September 1993,
Biochemical and biophysical research communications,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
February 1989,
Proceedings of the National Academy of Sciences of the United States of America,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
July 1988,
Science (New York, N.Y.),
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
December 2002,
The Journal of clinical endocrinology and metabolism,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
December 1995,
The Journal of clinical endocrinology and metabolism,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
May 2004,
Calcified tissue international,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
May 1998,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
M C Etienne, and
J L Fischel, and
G Milano, and
P Formento, and
J L Formento, and
M Francoual, and
M Frenay, and
M Namer
December 1995,
Calcified tissue international,
