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In an attempt to determine factors that are related to atrial natriuretic factor (ANF) release in normal subjects, 10 male volunteers were studied at rest supine, sitting and during treadmill exercise. Echocardiography was used to measure atrial volumes, and a Swan-Ganz catheter was used to measure right atrial pressure and pulmonary artery wedge pressure. Right ventricular ANF increased from 33 +/- 22 pg/ml supine to 72 +/- 32 pg/ml at peak exercise (p less than 0.001). When heart rate, atrial volume and atrial phasic pressure were combined to calculate atrial minute circumferential wall stress, a significant relationship between left and right atrial values for this variable and ANF was present. An association between norepinephrine (NE) and ANF was also present, but in a multivariate analysis it was not significant. This probably does not represent cause and effect but rather an association due to the relationship between NE and heart rate.
K F Hossack, and
O V Adair, and
S T Crowley
May 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
K F Hossack, and
O V Adair, and
S T Crowley
April 1991,
Aviation, space, and environmental medicine,
K F Hossack, and
O V Adair, and
S T Crowley
October 1990,
The Journal of laboratory and clinical medicine,
K F Hossack, and
O V Adair, and
S T Crowley
February 1989,
Transplantation proceedings,
K F Hossack, and
O V Adair, and
S T Crowley
June 1988,
Acta endocrinologica,
K F Hossack, and
O V Adair, and
S T Crowley
October 1989,
Clinical physiology (Oxford, England),
K F Hossack, and
O V Adair, and
S T Crowley
October 1995,
The Journal of clinical endocrinology and metabolism,
K F Hossack, and
O V Adair, and
S T Crowley
December 1984,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
K F Hossack, and
O V Adair, and
S T Crowley
January 1989,
European journal of applied physiology and occupational physiology,
K F Hossack, and
O V Adair, and
S T Crowley
September 1987,
Acta endocrinologica,
