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In a study of the vectorial secretion of proteins by bovine aortic arch endothelial cells, we found that the extracellular matrix macromolecules collagen and fibronectin as well as several matrix-degrading metalloproteinases were secreted selectively in the basal direction. In contrast, the tissue inhibitor of metalloproteinases showed only a weak preference for the basal direction. Three proteins at 18-35 kDa were secreted with preference apically, counter to the basal secretion of approximately 70% of the total secreted protein. As expected, rabbit synovial fibroblasts, which were used as a control, secreted proteins, including collagen, gelatin-degrading proteinases, and casein-degrading proteinases, equally in apical and basal directions. The basal secretion of collagen, fibronectin, gelatinases, and tissue inhibitor of metalloproteinases by bovine aortic arch endothelial cells suggests that the structural and functional polarity of these cells is manifested, in part, at the level of polarized secretion of matrix-related proteins.
E N Unemori, and
K S Bouhana, and
Z Werb
April 1997,
The American journal of physiology,
E N Unemori, and
K S Bouhana, and
Z Werb
February 1994,
International journal of cancer,
E N Unemori, and
K S Bouhana, and
Z Werb
January 1995,
Experimental nephrology,
E N Unemori, and
K S Bouhana, and
Z Werb
April 1994,
Brain pathology (Zurich, Switzerland),
E N Unemori, and
K S Bouhana, and
Z Werb
March 1987,
Journal of cell science,
E N Unemori, and
K S Bouhana, and
Z Werb
October 1993,
Cancer research,
E N Unemori, and
K S Bouhana, and
Z Werb
December 2008,
Molecular and cellular neurosciences,
E N Unemori, and
K S Bouhana, and
Z Werb
October 1997,
Cancer,
E N Unemori, and
K S Bouhana, and
Z Werb
November 1989,
Archives of biochemistry and biophysics,
E N Unemori, and
K S Bouhana, and
Z Werb
January 1995,
Progress in growth factor research,
