-transparent.png){kind=logo}
1. In subjects with normal renal function there was a strong positive correlation between serum concentrations of 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol, as measured by competitive protein-binding assay. 2. The 24,25-dihydroxycholecalciferol concentration was about 7% of the prevailing 25-hydroxycholecalciferol concentration. 3. In contrast, sera from anephric patients contained very low or undetectable amounts of 24,25-dihydroxycholecalciferol even after the serum 25-hydroxycholecalciferol concentrations in these patients had been elevated by oral administration of 25-hydroxycholecalciferol. 4. In a further group of anephric patients, all having normal serum 25-hydroxycholecalciferol concentrations, no radioactively labelled 24,25-dihydroxycholecalciferol was formed from an injected pulse dose of [3H,14C]cholecalciferol. 5. These results indicate that in man the kidney is the major site of 24-hydroxylation of 25-hydroxycholecalciferol.
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
October 1984,
Clinical nephrology,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
March 1979,
British medical journal,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
November 1991,
The Journal of nutrition,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
May 1977,
Calcified tissue research,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
June 1976,
Biochemical and biophysical research communications,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
December 1976,
Calcified tissue research,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
July 1984,
Endocrinology,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
December 1982,
Acta endocrinologica,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
January 1978,
Advances in experimental medicine and biology,
C M Taylor, and
E B Mawer, and
J E Wallace, and
J St John, and
M Cochran, and
R G Russell, and
J A Kanis
June 1976,
The Journal of nutrition,
