Comparison of electrode materials for the use of retinal prosthesis. 2011

Niina Onnela, and Hirotaka Takeshita, and Yoshiuki Kaiho, and Toshiya Kojima, and Risato Kobayashi, and Tetsu Tanaka, and Jari Hyttinen
Department of Biomedical Engineering, Tampere University of Technology, Tampere, Finland. niina.onnela@tut.fi

Retinal implants may provide vision for people suffering from photoreceptor degeneration caused by different eye diseases. Electrode size in retinal implant should be decreased in order to increase the resolution provided by the implant. We defined electric properties of five different electrode materials (Au, Ir-b, Ti, TiN, Pt-b) widely used in retinal prostheses. The comparison of different electrode materials requires that the electrical properties of different materials are defined using exactly the same measurement conditions and devices. Existing studies about electrode material properties are often made using slightly different measurement parameters or electrode processing conditions making the comparison between different materials difficult. Here, the electrochemical characterization included cyclic voltammetry and electrochemical impedance spectroscopy. Ir-b and Pt-b had greater charge injection capacity than other materials. The fabricated material samples showed that in this experiment the electrode diameter larger than 200 μm should be used to suppress irreversible reaction of stimulus electrodes with the needed stimulus currents. Thus, either we have to find novel electrode materials or surface treatment methods to decrease the electrode area providing increased electrode and pixel number of the prosthesis or we have to show that stimulus currents smaller than 40 μA are enough to induce phosphenes.

UI MeSH Term Description Entries
D007495 Iridium A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D010984 Platinum A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae". Platinum Black
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D004566 Electrodes Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum. Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D004567 Electrodes, Implanted Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body. Implantable Electrodes,Implantable Stimulation Electrodes,Implanted Electrodes,Implanted Stimulation Electrodes,Electrode, Implantable,Electrode, Implantable Stimulation,Electrode, Implanted,Electrode, Implanted Stimulation,Electrodes, Implantable,Electrodes, Implantable Stimulation,Electrodes, Implanted Stimulation,Implantable Electrode,Implantable Stimulation Electrode,Implanted Electrode,Implanted Stimulation Electrode,Stimulation Electrode, Implantable,Stimulation Electrode, Implanted,Stimulation Electrodes, Implantable,Stimulation Electrodes, Implanted
D006046 Gold A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D014025 Titanium A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.

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