BIOMAT Database Logo BIOMAT Database Logo

Multicomponent reactions of ammonium thiocyanate, acyl chlorides, alkyl bromides, and enaminones: a facile one-pot synthesis of thiophenes. 2011

Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, PO Box 163, Qaemshahr, Iran. zshossaini@yahoo.com

An efficient synthesis of thiophene derivatives is described via one-pot reaction between ammonium thiocyanate, acyl chlorides, α-halocarbonyls, and enaminones under solvent-free conditions at 65 °C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.

UI MeSH Term Description Entries
D001966 Bromine A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested. Bromine-79,Bromine 79
D002713 Chlorine An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. Chlorine Gas,Chlorine-35,Cl2 Gas,Chlorine 35,Gas, Chlorine,Gas, Cl2
D000473 Alkanes The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkane
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine
D013861 Thiocyanates Organic derivatives of thiocyanic acid which contain the general formula R-SCN. Rhodanate,Rhodanates
D013876 Thiophenes A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur. Thiophene
D060326 Chemistry Techniques, Synthetic Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs. Inorganic Synthesis,Inorganic Synthesis Methods,Inorganic Synthesis Techniques,Methods of Inorganic Synthesis,Methods of Organic Synthesis,Methods of Peptide Synthesis,Organic Synthesis,Organic Synthesis Methods,Organic Synthesis Techniques,Peptide Synthesis Methods,Peptide Synthesis Techniques,Peptide Synthesis, Synthetic,Synthetic Chemistry Techniques,Synthetic Peptide Synthesis,Chemistry Technique, Synthetic,Inorganic Syntheses,Inorganic Synthesis Method,Inorganic Synthesis Technique,Method, Inorganic Synthesis,Method, Organic Synthesis,Method, Peptide Synthesis,Methods, Inorganic Synthesis,Methods, Organic Synthesis,Methods, Peptide Synthesis,Organic Syntheses,Organic Synthesis Technique,Peptide Syntheses, Synthetic,Peptide Synthesis Method,Peptide Synthesis Technique,Syntheses, Inorganic,Syntheses, Organic,Syntheses, Synthetic Peptide,Synthesis Method, Inorganic,Synthesis Method, Peptide,Synthesis Methods, Inorganic,Synthesis Methods, Peptide,Synthesis Technique, Inorganic,Synthesis Technique, Organic,Synthesis Technique, Peptide,Synthesis Techniques, Inorganic,Synthesis Techniques, Organic,Synthesis Techniques, Peptide,Synthesis, Inorganic,Synthesis, Organic,Synthesis, Synthetic Peptide,Synthetic Chemistry Technique,Synthetic Peptide Syntheses,Technique, Inorganic Synthesis,Technique, Organic Synthesis,Technique, Peptide Synthesis,Technique, Synthetic Chemistry,Techniques, Inorganic Synthesis,Techniques, Organic Synthesis,Techniques, Peptide Synthesis,Techniques, Synthetic Chemistry

Related Publications

Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
A facile one-pot synthesis of alkyl aryl sulfides from aryl bromides.
April 2004, The Journal of organic chemistry,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.
August 2009, Molecular diversity,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Facile and efficient synthesis of functionalized iminothiopyran and isothiochromen via one-pot multicomponent reactions.
February 2011, Molecular diversity,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Facile one-pot synthesis of S-alkyl thiocarbamates.
May 2003, The Journal of organic chemistry,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
A mild and facile one-pot synthesis of N-methyl-acyl-pyrroles.
April 2010, Molecules (Basel, Switzerland),
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions.
September 2013, Organic letters,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides.
September 2021, Molecules (Basel, Switzerland),
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Dihydropyrrole-3-thiones: one-pot synthesis from propargylamines, acyl chlorides and sodium sulfide.
August 2023, Organic & biomolecular chemistry,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
Synthesis of cyclopentadiene-fused chromanones via one-pot multicomponent reactions.
March 2013, The Journal of organic chemistry,
Zinatossadat Hossaini, and Faramarz Rostami-Charati, and Samira Soltani, and Anwar Mirzaei, and Kayhaneh Berijani
One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions.
January 2014, Beilstein journal of organic chemistry,
Copied contents to your clipboard!