-transparent.png){kind=logo}
Dihydropyrrole-3-thiones: one-pot synthesis from propargylamines, acyl chlorides and sodium sulfide. 2023
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russian Federation. boris_trofimov@irioch.irk.ru.
An efficient one-pot synthesis of 1,2,5-trisubstituted-1,2-dihydro-3H-pyrrole-3-thiones (up to 91% yield), representatives of essentially new heterocyclic systems, by the successive treatment of available propargylamines with acyl chlorides (PdCl2/CuI/Ph3P/Et3N, toluene, 40-45 °C, 3 h) and sodium sulfide (Na2S·9H2O, EtOH, 20-25 °C, 7 h) has been developed. The synthesis comprises the addition of sulfide anions to the formed aminoacetylenic ketones followed by dehydrative cyclization of the prototropically rearranged adducts.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
October 2018,
Organic letters,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
May 2006,
Organic letters,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
May 2006,
The Journal of organic chemistry,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
August 2022,
The Journal of organic chemistry,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
January 2014,
Organic & biomolecular chemistry,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
November 2010,
Molecular diversity,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
August 2014,
Organic letters,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
January 2007,
Journal of combinatorial chemistry,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
July 2019,
Organic & biomolecular chemistry,
Pavel A Volkov, and
Kseniya O Khrapova, and
Ekaterina M Vyi, and
Anton A Telezhkin, and
Ivan A Bidusenko, and
Alexander I Albanov, and
Elena Yu Schmidt, and
Boris A Trofimov
November 2011,
Molecular diversity,
