-transparent.png){kind=logo}
Fluorocitrate (FC), a selective inhibitor of glial cell respiration, was used to estimate the extent to which glial cells contain adenylate cyclase-coupled beta-adrenoceptors in rat brain slices. The drug blocked 75-95% of the elevation of cyclic AMP caused by the beta-agonist, isoproterenol, in the 4 forebrain regions sampled (frontal and parietal cortex, caudate nucleus, olfactory tubercle). Intracellular recording of neurons in the treated slices confirmed that they were unaffected by FC. Treatment with the neurotoxin, kainic acid, eliminated all electrophysiological activity but did not affect the cAMP response. The results indicate that glial cells contain the preponderance of adenylate-cyclase-coupled beta-adrenoceptors in slices of the rat forebrain and may constitute an important target of the central noradrenergic system in vivo.
E A Stone, and
F M Sessler, and
W M Liu
January 1984,
Journal of cardiovascular pharmacology,
E A Stone, and
F M Sessler, and
W M Liu
May 1993,
European journal of pharmacology,
E A Stone, and
F M Sessler, and
W M Liu
January 1976,
Recent progress in hormone research,
E A Stone, and
F M Sessler, and
W M Liu
March 1975,
Biochemical pharmacology,
E A Stone, and
F M Sessler, and
W M Liu
October 1985,
Naunyn-Schmiedeberg's archives of pharmacology,
E A Stone, and
F M Sessler, and
W M Liu
January 1990,
British journal of clinical pharmacology,
E A Stone, and
F M Sessler, and
W M Liu
July 1982,
Proceedings of the National Academy of Sciences of the United States of America,
E A Stone, and
F M Sessler, and
W M Liu
January 1987,
Chronobiology international,
E A Stone, and
F M Sessler, and
W M Liu
August 1984,
Nippon Ganka Gakkai zasshi,
E A Stone, and
F M Sessler, and
W M Liu
January 1980,
Journal of neurochemistry,
