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Effect of alpha-latrotoxin on the concentration level of free calcium [( Ca2+]in) in the rat brain synaptosomes and dependence of the activity of "latrotoxin" channels on [Ca2+]in were studied using fluorescent calcium probe quin-2. It is shown that alpha-latrotoxin exerts effect on calcium permeability of plasmalemma and does not induce calcium ejection from the intracellular compartments. A lag-period is characteristic of alpha-latrotoxin action. A degree of the [Ca2+]in increase in synaptosomes depends on the toxin concentration. When [Ca2+]in increases as a result of preliminary potassium depolarization of plasmalemma of synaptosomes, the amount of incoming calcium ions followed by the toxin effect as well as the calcium input rate considerably decrease. Inactivation of calcium-transferring channels induced by alpha-latrotoxin is not a result of a change in the potential on the membrane, as during the blockage of potential-depending calcium channels by D-600, an increase of KCl in the incubation medium does not influence the alpha-latrotoxin action. Differences in the properties of alpha-latrotoxin channels are discussed in synaptosomes and BLM.
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 1988,
Ukrainskii biokhimicheskii zhurnal (1978),
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 1987,
Ukrainskii biokhimicheskii zhurnal (1978),
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 1987,
Ukrainskii biokhimicheskii zhurnal (1978),
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
June 1996,
Bioorganicheskaia khimiia,
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 1982,
Toxicon : official journal of the International Society on Toxinology,
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
June 2003,
Neurochemistry international,
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
October 1988,
Proceedings of the National Academy of Sciences of the United States of America,
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
August 1990,
Biokhimiia (Moscow, Russia),
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 2002,
Doklady. Biochemistry and biophysics,
N G Gimmel'reĭkh, and
E A Saĭchenko, and
L G Storchak, and
V K Lishko
January 1989,
Ukrainskii biokhimicheskii zhurnal (1978),
