-transparent.png){kind=logo}
The aim of the present study is to elucidate the possible significance of metabolic control of the calcium permeability of synaptosomes induced by alpha-latrotoxin. The alpha-latrotoxin influence of processes of GABA release and reuptake is shown to depend on synaptosomal metabolism. It has been found that incubation by the synaptosomes during one hour at 37 degrees C or their treatment by 10(-3) M monoiodacetate during 10 min at 10 degrees C or at room temperature completely abolished or at least strongly decreased the ability of alpha-latrotoxin to induce the calcium influx. Under the same conditions the ability of alpha-latrotoxin to activate the GABA release and inhibit the GABA reuptake do not change. It is concluded that only formation of calcium channels by alpha-latrotoxin is strictly controlled by the level of synaptosomal metabolism.
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
January 1982,
Toxicon : official journal of the International Society on Toxinology,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
January 1990,
Ukrainskii biokhimicheskii zhurnal (1978),
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
June 1996,
Bioorganicheskaia khimiia,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
February 1994,
The Journal of membrane biology,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
February 1999,
The Journal of biological chemistry,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
March 1996,
The Journal of biological chemistry,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
September 1992,
Toxicon : official journal of the International Society on Toxinology,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
January 1988,
Biofizika,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
January 2007,
Doklady. Biochemistry and biophysics,
N G Gimmel'reĭkh, and
T A Pivneva, and
L G Storchak, and
E V Nikolishina, and
V K Lishko
September 1992,
FEMS microbiology immunology,
