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The management of opportunistic infections is a significant problem in acquired immunodeficiency syndrome (AIDS) and the development of more effective chemotherapeutic agents is needed. We present the ocular manifestations of an AIDS-like disease in rhesus monkeys experimentally infected with simian immunodeficiency virus (SIV) at the Delta Regional Primate Research Center. These findings consisted of rubeosis in the anterior segment and retinitis, optic neuritis, choroiditis and panophthalmitis in the posterior segment of the eye. Investigation of the retinas by electron microscopy revealed SIV in both eyes of one animal and a herpes virus in two animals. Serology confirmed cytomegalovirus (CMV) as the likely agent. This primate model will prove useful for both further investigations of the possible interaction between immunosuppressive lentiviruses and CMV in ocular disease and antiviral drug testing.
M D Conway, and
P Didier, and
B Fairburn, and
K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
June 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M D Conway, and
P Didier, and
B Fairburn, and
K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
April 1984,
Laboratory animal science,
M D Conway, and
P Didier, and
B Fairburn, and
K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
January 1984,
Science (New York, N.Y.),
M D Conway, and
P Didier, and
B Fairburn, and
K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
October 1983,
Lancet (London, England),
M D Conway, and
P Didier, and
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K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
September 1988,
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M D Conway, and
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K F Soike, and
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M S Insler
December 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M D Conway, and
P Didier, and
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K F Soike, and
L Martin, and
M Murphey-Corb, and
N Meiners, and
M S Insler
October 1987,
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M D Conway, and
P Didier, and
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M Murphey-Corb, and
N Meiners, and
M S Insler
February 1987,
DTW. Deutsche tierarztliche Wochenschrift,
M D Conway, and
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M S Insler
January 1986,
Progress in allergy,
M D Conway, and
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M Murphey-Corb, and
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M S Insler
February 1992,
Medicina clinica,
