-transparent.png){kind=logo}
A syndrome of acquired immunodeficiency has been identified in a group of rhesus monkeys (Macaca mulatta) which died at the California Primate Research Center. Clinical evaluation of these animals revealed that 50% or more had lymphadenopathy, weight loss, and diarrhea. At least 30% had splenomegaly, fever, cutaneous abscesses and/or arthritis/myositis. Two animals had fibrosarcomas. Anemia was seen in 19 animals, lymphopenia in 14, granulocytopenia in four and thrombocytopenia in three. Hepatitis was diagnosed histopathologically in 13. Electrophoresis revealed hypoproteinemia, hypoalbuminemia and hypogammaglobulinemia. Numerous bacterial, protozoal, and viral agents were identified including cytomegalovirus and leukocyte-associated herpesvirus. Pathologic lesions included severe post-reactive depletion of lymphocytes in germinal centers and paracortical regions of lymph nodes. Clinical and pathologic changes indicate an acquired immunodeficiency syndrome which has some similarities to AIDS in humans. This disease in monkeys may provide a model for studying that disease.
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
June 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
July 1986,
Journal of the National Cancer Institute,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
June 1992,
The American journal of pathology,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
August 1990,
Current eye research,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
September 1987,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
December 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
November 1985,
Veterinary immunology and immunopathology,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
October 1991,
Laboratory investigation; a journal of technical methods and pathology,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
January 1986,
Progress in allergy,
R V Henrickson, and
D H Maul, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
S Prahalada, and
J L Sever, and
D L Madden, and
M B Gardner
October 1987,
Journal of virology,
