-transparent.png){kind=logo}
Osteogenic tumours from c-fos (MT-c-fos-LTR)-transgenic mice and from mice infected with the v-fos-bearing FBR murine osteosarcoma virus (FBR MSV) showed close morphological and neoplastic similarities. Fos mRNA expression was elevated in both types of tumours, and expression of several genes characteristic of differentiated bone cells was either lower, enhanced, or not detectable in comparison to that in normal bone. Tumour-derived cell lines showed variable levels of exogenous fos expression; bone-cell-specific genes were similarly expressed in both primary tumours and tumour-derived cell lines. Upon transplantation the tumour cells formed fibrosarcomas, some of which contained areas of focal osseochondrous differentiation. Non-tumorigenic cell lines established from bone tissue of normal and MT-c-fos-LTR transgenic mice showed osteoblastic characteristics, whereas no parathyroid hormone (PTH) response was observed in transgenic tumour cell lines in spite of high alkaline phosphatase activity. These data indicate that deregulated fos expression interferes with terminal osteogenic differentiation in v-fos- and c-fos-induced bone tumours.
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
July 1993,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
December 1988,
Differentiation; research in biological diversity,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
September 1989,
British journal of cancer,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
June 2015,
Nature communications,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
November 1990,
The Journal of general virology,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
July 2002,
British journal of cancer,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
March 1996,
Leukemia,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
September 2015,
Veterinary and comparative oncology,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
August 1995,
Tissue & cell,
R Goralczyk, and
E I Closs, and
U Rüther, and
E F Wagner, and
P G Strauss, and
V Erfle, and
J Schmidt
September 1996,
Journal of virology,
