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Our previous studies have demonstrated that oxytocin (OXT) in the central nervous system plays a role in pain modulation. Many studies have found that caudate nucleus (CdN) enriches OXT and OXT receptors by the methods of historadioautograph and gene expression. The communication was designed to investigate OXT effect in the rat CdN on pain modulation. The results showed that (1) intra-CdN microinjection of OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold, whereas the local administration of OXT increased the pain threshold in a dose-dependent manner; (2) OXT receptor antagonist can attenuate the analgesic role induced intra-CdN administration of OXT; and (3) pain stimulation could increase OXT concentration in the CdN perfusion liquid. The data suggested that OXT in the CdN was involved in this pain process via OXT receptors.
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Xi-Qing Yan, and
Da-Xin Wang
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Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
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Da-Xin Wang
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Neuropeptides,
Jun Yang, and
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Ying Zhao, and
Pei-Yong Qiu, and
Lu Lu, and
Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
August 1963,
Science (New York, N.Y.),
Jun Yang, and
Yan-Juan Pan, and
Ying Zhao, and
Pei-Yong Qiu, and
Lu Lu, and
Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
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Neuropeptides,
Jun Yang, and
Yan-Juan Pan, and
Ying Zhao, and
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Lu Lu, and
Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
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Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
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Yan-Juan Pan, and
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Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
June 1970,
Brain research,
Jun Yang, and
Yan-Juan Pan, and
Ying Zhao, and
Pei-Yong Qiu, and
Lu Lu, and
Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
November 2019,
Peptides,
Jun Yang, and
Yan-Juan Pan, and
Ying Zhao, and
Pei-Yong Qiu, and
Lu Lu, and
Peng Li, and
Feng Chen, and
Xi-Qing Yan, and
Da-Xin Wang
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