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New polymeric colloids functionalized with 2,4-diaminotriazine residues have been prepared. The functionalities provide a triple hydrogen bond motif with a donor-acceptor-donor (DAD) pattern. The colloids are based on cross-linked poly-4-methoxymethyl styrene and are polymerized by means of surfactant-free emulsion polymerization. The reaction pathway including five steps was successfully tracked and verified via (13)C CP/MAS solid-state NMR. Characterization of the colloids was done by combined static and dynamic light scattering and indicates a compact spherical particle shape. In solvents with the appropriate polarity, intercolloidal hydrogen bonding was enabled, including colloidal aggregation. In highly dilute solutions of THF, this aggregation was recordable by means of time-resolved static light scattering experiments. If THF was saturated with uracil, then aggregation could be completely inhibited. Uracil bears a triple hydrogen bond motif of the form acceptor-donor-acceptor (ADA) and is a direct antagonist of 2,4-diaminotriazine. The charging of the colloids with uracil via hydrogen bond formation as a typical molecular recognition mechanism could be confirmed by IR spectroscopy.
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
April 1950,
La Riforma medica,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
May 2018,
Macromolecular rapid communications,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
October 2014,
ChemMedChem,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
January 2018,
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
June 2009,
Journal of the American Chemical Society,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
October 2016,
Chemical communications (Cambridge, England),
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
February 2005,
Chemical communications (Cambridge, England),
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
December 1991,
Biophysical journal,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
October 2013,
The Journal of chemical physics,
Frank M Bayer, and
Mingxue Tang, and
Rolf Michels, and
Claudia Schmidt, and
Klaus Huber
October 2015,
Chemical communications (Cambridge, England),
