BIOMAT Database Logo BIOMAT Database Logo

Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors. 1990

D T Wong, and R W Fuller, and D W Robertson
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.

The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.

UI MeSH Term Description Entries
D005473 Fluoxetine The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Fluoxetin,Fluoxetine Hydrochloride,Lilly-110140,N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine,Prozac,Sarafem,Lilly 110140,Lilly110140
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012702 Serotonin Antagonists Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. 5-HT Antagonist,5-HT Antagonists,5-Hydroxytryptamine Antagonist,5-Hydroxytryptamine Antagonists,Antiserotonergic Agent,Antiserotonergic Agents,Serotonin Antagonist,Serotonin Blockader,Serotonin Blockaders,Serotonin Receptor Antagonist,Serotonin Receptor Blocker,Antagonists, 5-HT,Antagonists, 5-Hydroxytryptamine,Antagonists, Serotonin,Serotonin Receptor Antagonists,Serotonin Receptor Blockers,5 HT Antagonist,5 HT Antagonists,5 Hydroxytryptamine Antagonist,5 Hydroxytryptamine Antagonists,Agent, Antiserotonergic,Agents, Antiserotonergic,Antagonist, 5-HT,Antagonist, 5-Hydroxytryptamine,Antagonist, Serotonin,Antagonist, Serotonin Receptor,Antagonists, 5 HT,Antagonists, 5 Hydroxytryptamine,Antagonists, Serotonin Receptor,Blockader, Serotonin,Blockaders, Serotonin,Blocker, Serotonin Receptor,Blockers, Serotonin Receptor,Receptor Antagonist, Serotonin,Receptor Antagonists, Serotonin,Receptor Blocker, Serotonin,Receptor Blockers, Serotonin
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer

Related Publications

D T Wong, and R W Fuller, and D W Robertson
Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors.
August 1991, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
D T Wong, and R W Fuller, and D W Robertson
Fluoxetine, a selective serotonin uptake inhibitor.
April 1978, Clinical pharmacology and therapeutics,
D T Wong, and R W Fuller, and D W Robertson
Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.
January 1995, Advances in experimental medicine and biology,
D T Wong, and R W Fuller, and D W Robertson
Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo.
October 1992, Neuropharmacology,
D T Wong, and R W Fuller, and D W Robertson
Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain.
June 1993, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
D T Wong, and R W Fuller, and D W Robertson
Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors.
April 1983, Biochemical pharmacology,
D T Wong, and R W Fuller, and D W Robertson
[Selective serotonin uptake inhibitors and pancreatitis].
January 2001, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
D T Wong, and R W Fuller, and D W Robertson
[Selective serotonin uptake inhibitors and interactions].
August 1998, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
D T Wong, and R W Fuller, and D W Robertson
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
March 2009, Bioorganic & medicinal chemistry,
D T Wong, and R W Fuller, and D W Robertson
New indole derivatives as potent and selective serotonin uptake inhibitors.
April 1993, Journal of medicinal chemistry,
Copied contents to your clipboard!