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In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause by secretin or vasoactive intestinal peptide. Ethanol potentiated the increase in adenylate cyclase activity and cellular adenosine 3':5'-monophosphate caused by secretin or vasoactive intestinal peptide. This potentiating action was reversible and could also be detected with straight-chain alcohols having fewer than seven carbon atoms. At sufficiently high concentrations, straight-chain alcohols having more than two carbon atoms inhibited the action of secretin or vasoactive intestinal peptide on adenylate cyclase activity, and this and this action was irreversible.
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P Robberecht, and
J D Gardner
October 1979,
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E R Uhlemann, and
P Robberecht, and
J D Gardner
November 1977,
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E R Uhlemann, and
P Robberecht, and
J D Gardner
July 1986,
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E R Uhlemann, and
P Robberecht, and
J D Gardner
December 1975,
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E R Uhlemann, and
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J D Gardner
June 1983,
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E R Uhlemann, and
P Robberecht, and
J D Gardner
November 1978,
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E R Uhlemann, and
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J D Gardner
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E R Uhlemann, and
P Robberecht, and
J D Gardner
November 1986,
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E R Uhlemann, and
P Robberecht, and
J D Gardner
March 1986,
Regulatory peptides,
E R Uhlemann, and
P Robberecht, and
J D Gardner
May 1982,
The American journal of physiology,
