-transparent.png){kind=logo}
Cell-mediated immune reactions play the most important role in the pathogenesis of chronic viral and auto-immune hepatitis. Cellular cytotoxicity (CC) of peripheral blood lymphocytes against autologous hepatocytes isolated from liver biopsies was studied in 29 children with different types of hepatitis B surface antigen (HBsAg)-positive hepatitis. Children with chronic hepatitis B showed higher cytotoxicity than control patients. However, a correlation of cytotoxicity to serum amino-transferases, HBeAg-/Anti-HBe-status, and hepatitis B virus DNA in serum could not be found. Children with a higher percentage of hepatitis B core antigen (HBcAg) expression in their liver tissue presented lower CC values, and vice versa. This supports the hypothesis that virus elimination occurs via T-cell attack against HBcAg expressing hepatocytes. Furthermore, children with a longer duration of chronic hepatitis B had considerably higher cytotoxicity values. Possibly, CC plays a role in perpetuating liver damage after infection with hepatitis B virus.
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
February 1984,
Gut,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
April 1985,
Zeitschrift fur Gastroenterologie,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
April 1984,
Liver,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
October 1979,
Clinical and experimental immunology,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
January 1984,
Hepatology (Baltimore, Md.),
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
December 1982,
Journal of immunology (Baltimore, Md. : 1950),
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
May 1995,
Clinical and experimental immunology,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
April 1985,
Zeitschrift fur Gastroenterologie,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
January 1981,
Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum,
K M Keller, and
T Poralla, and
H P Dienes, and
S Wirth, and
W Baumann
August 1986,
Clinical immunology and immunopathology,
