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We report a case of hyperthyroidism due to inappropriate thyrotrophin (TSH) secretion in a patient with selective pituitary resistance to thyroid hormone action. Symptoms of hyperthyroidism in patients with this disorder are usually mild, implying some peripheral tissue resistance to the metabolic effects of thyroid hormone. Our patient had unusually severe symptoms, including marked weight loss and cardiac arrythmias which required carbimazole and beta-blocker therapy for control. Somatostatin was ineffective in suppressing TSH secretion. The introduction of sensitive thyrotrophin assays should facilitate the accurate diagnosis of TSH-induced hyperthyroidism and avoid inappropriate treatment.
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
February 1992,
Acta medica portuguesa,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
January 1992,
The American journal of medicine,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
July 1983,
Clinical endocrinology,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
January 1982,
The Journal of clinical endocrinology and metabolism,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
June 1991,
The Netherlands journal of medicine,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
September 1986,
Acta endocrinologica,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
March 1997,
Clinical obstetrics and gynecology,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
January 1989,
The Journal of clinical endocrinology and metabolism,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
March 1993,
Endocrine regulations,
A W Chan, and
I A MacFarlane, and
C van Heyningen, and
P M Foy
May 1984,
Postgraduate medical journal,
