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We have examined the effect of synthetic human cholecystokinin (CCK-33 and CCK-8) on pancreatic blood flow and protein output in anesthetized dogs. Human CCK-33 and CCK-8 increased pancreatic blood flow and protein output in a dose-related manner. There were no significant differences in increasing pancreatic blood flow between human CCK-33 and CCK-8, and increases in blood flow were closely related to the increase of the pancreatic enzyme secretion. L-364,718 (20 nmol/kg) caused a potent inhibition of CCK-stimulated pancreatic blood flow as well as protein output. The degree of inhibition by L-364,718 was dependent on the amount of CCK infused. This study demonstrates that increasing effect on pancreatic blood flow may be one of the biological actions of CCK mediated via CCK receptor. The CCK-33, one of longer molecular forms of CCK, is an important biological stimulator of pancreatic blood flow as well as of exocrine pancreatic secretion.
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
February 1988,
Biochemical and biophysical research communications,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
April 1986,
Neuropeptides,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
March 1991,
Surgery,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
February 1991,
Gastroenterologia Japonica,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
March 1984,
The American journal of physiology,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
January 1983,
Peptides,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
April 1987,
Neuropeptides,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
August 1983,
Digestive diseases and sciences,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
June 1972,
Gut,
R Doi, and
R Hosotani, and
K Inoue, and
M Kogire, and
S Sumi, and
N Fujii, and
H Yajima, and
P L Rayford, and
T Tobe
September 1988,
The Journal of physiology,
