BIOMAT Database Logo BIOMAT Database Logo

[Nucleotide specificity of rat liver thiamine pyrophosphokinase]. 1979

I M Artsukevich

The nucleotide specificity of thiamine pyrophosphokinase from rat liver was studied. The enzyme was found to possess a sufficiently wide substrate specificity. Any of the nucleotides can be a donor of the pyrophosphate groups for TDP biosynthesis at two pH optima of the enzyme in the T-kinase reaction under the Mg2++/NTP optimal ratio. The minimal requirement for the substrate structure allowing to predict the position of the split nucleotide phosphoester bond was postulated.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D010770 Phosphotransferases A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7. Kinases,Phosphotransferase,Phosphotransferases, ATP,Transphosphorylase,Transphosphorylases,Kinase,ATP Phosphotransferases
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013379 Substrate Specificity A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. Specificities, Substrate,Specificity, Substrate,Substrate Specificities
D013836 Thiamin Pyrophosphokinase An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2. Thiamine Pyrophosphokinase,Pyrophosphokinase, Thiamin,Pyrophosphokinase, Thiamine
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

I M Artsukevich
[Mechanisms of rat liver thiamine pyrophosphokinase activation by magnesium ions].
January 1979, Biokhimiia (Moscow, Russia),
I M Artsukevich
[Substrate specificity of thiamine pyrophosphokinase from brewer's yeast].
May 1975, Doklady Akademii nauk SSSR,
I M Artsukevich
Subcellular distribution of thiamine pyrophosphokinase activity in rat liver and erythrocytes.
December 1970, Biochimica et biophysica acta,
I M Artsukevich
Affinity chromatography of thiamine pyrophosphokinase from rat brain on thiamine monophosphate-agarose.
January 1979, Methods in enzymology,
I M Artsukevich
Ribosephosphate pyrophosphokinase (rat liver).
January 1978, Methods in enzymology,
I M Artsukevich
[Studies on thiamine pyrophosphokinase].
January 1962, Archiv fur Mikrobiologie,
I M Artsukevich
Subcellular distribution of thiamine-pyrophosphokinase and thiamine-pyrophosphatase activities in rat isolated enterocytes.
January 1977, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
I M Artsukevich
[On a thiamine pyrophosphokinase in the rat pancreatic juice].
October 1967, Zeitschrift fur Ernahrungswissenschaft,
I M Artsukevich
[Phosphorylation of some thiamine analogs by yeast thiamine pyrophosphokinase].
October 1976, Biokhimiia (Moscow, Russia),
I M Artsukevich
[Thiamine pyrophosphokinase of pig heart muscles].
December 1969, Seikagaku. The Journal of Japanese Biochemical Society,
Copied contents to your clipboard!