BIOMAT Database Logo BIOMAT Database Logo

Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration. 2012

Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China.

Pharmacokinetics of mequindox (MEQ) and its metabolites were determined in rats after intravenous (i.v.) and oral (p.o.) administration of MEQ at a single dose of 10 mg kg(-1) bodyweight. After both administrations, MEQ and five of its metabolites were quantified, except M4, whereas M1 and M2 were the predominant ones. The areas under the concentration-time curves (h ng mL(-1)) of MEQ, M1, M2, M3, M5 and M10 after i.v. administration were 7559±495, 6354±2761, 5586±2337, 1034±160, 2370±791 and 1813±622, respectively, whereas after p.o. administration, remained as 2809±40, 4361±3544, 4351±1046, 1444±814, 3864±305 and 1213±569, respectively. The elimination half-lives (h) of these compounds after i.v. administration were 3.48±0.80, 4.20±0.76, 6.25±2.41, 4.77±1.54, 4.69±1.62 and 16.89±5.15, respectively, and were 3.21±0.40, 3.66±1.06, 4.20±1.03, 8.91±5.99, 4.20±2.02 and 20.84±10.85 after p.o. administration, respectively. After p.o. administration, the bioavailability of MEQ was 37.16%. The results showed that MEQ was extensively metabolized in rats and rapidly absorbed after p.o. administration.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D011810 Quinoxalines Quinoxaline
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
March 2012, Molecular nutrition & food research,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of propranolol and its metabolites in horses after intravenous or oral administration.
November 2000, Biological & pharmaceutical bulletin,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of caffeine and its metabolites in horses after intravenous, intramuscular or oral administration.
November 1991, Chemical & pharmaceutical bulletin,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of verproside after intravenous and oral administration in rats.
April 2009, Archives of pharmacal research,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of dihydroergosine in rats after intravenous and oral administration.
January 1983, European journal of drug metabolism and pharmacokinetics,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of ozagrel and its metabolites after intravenous and oral administrations.
October 1997, Journal of pharmaceutical sciences,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of brucine after intravenous and oral administration to rats.
December 2011, Fitoterapia,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
[The pharmacokinetics of dihydroergocristine after intravenous and oral administration in rats].
November 1992, Arzneimittel-Forschung,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of alpha-dihydroergocryptine in rats after intravenous and oral administration.
July 1991, Arzneimittel-Forschung,
Guanghui Li, and Fan Yang, and Limin He, and Huanzhong Ding, and Na Sun, and Yingchun Liu, and Yiming Liu, and Qi Shan, and Yafei Li, and Zhenling Zeng
Pharmacokinetics of tramadol and its major metabolites in alpacas following intravenous and oral administration.
August 2012, Journal of veterinary pharmacology and therapeutics,
Copied contents to your clipboard!