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Seventeen specimens of orbital fatty tissue taken from cases of dysthyroid ophthalmopathy at the time of operation were observed by light and electron microscopy, and also by immunohistochemical staining. The pathological changes observed were infiltration of the chronic inflammatory cells, deposit of fibrin, sclerosis of vascular wall, occlusion of the vascular lumen, and accumulation of hydrophilic mucopolysaccharide. Immunoglobulin G was detected in fat cells and lymphocytes, and some of the infiltrating lymphocytes were determined to be T cells, by immunohistochemistry. These findings suggested that the pathology of the dysthyroid ophthalmopathy was closely related to the chronic inflammation induced by the immune reaction. The exophthalmos was considered to occur due to edema secondary to chronic inflammation and accumulation of the mucopolysaccharides.
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
April 1982,
Rinsho shinkeigaku = Clinical neurology,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
January 1990,
Ophthalmic plastic and reconstructive surgery,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
November 2001,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
July 1974,
Transactions of the ophthalmological societies of the United Kingdom,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
January 1988,
Ophthalmic plastic and reconstructive surgery,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
August 1977,
The Journal of clinical endocrinology and metabolism,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
January 1988,
Eye (London, England),
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
October 1971,
Nippon Ganka Gakkai zasshi,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
April 1982,
Ophthalmology,
R J Chen, and
T Kagoshima, and
Y Ishii, and
S Hori, and
Y Inoue
July 1986,
American family physician,
