Biomaterial Database

Changes in the orbital tissues and muscles dysthyroid ophthalmopathy. 1988

G M Bleeker

The Netherlands Ophthalmic Research Institute, Amsterdam.

The mysterious background of Graves' Disease is gradually disclosing more and more of the secrets of its origin. Since the problem is in principal confined to the orbit, the various stages of development can be found in the orbital tissues, and in particular as lymphocytic infiltrations in the extraocular muscles. It has become almost certain that Graves' Disease is a complicated auto-immune disorder.

UI	MeSH Term	Description	Entries
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009915	Orbit	Bony cavity that holds the eyeball and its associated tissues and appendages.	Eye Socket,Eye Sockets,Orbits,Socket, Eye,Sockets, Eye
D006111	Graves Disease	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).	Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D014890	Granulomatosis with Polyangiitis	A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.	Granulomatosis, Wegener's,Wegener Granulomatosis,Wegener's Granulomatosis,Granulomatosis with Polyangiitides,Granulomatosis, Wegener,Polyangiitides, Granulomatosis with,Polyangiitis, Granulomatosis with,with Polyangiitides, Granulomatosis,with Polyangiitis, Granulomatosis

Related Publications

G M Bleeker

MRI measurements of orbital tissues in dysthyroid ophthalmopathy.

November 2001, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,

G M Bleeker

The ocular and orbital circulations in dysthyroid ophthalmopathy.

July 1974, Transactions of the ophthalmological societies of the United Kingdom,

G M Bleeker

Hypoglobus following orbital decompression for dysthyroid ophthalmopathy.

January 1990, Ophthalmic plastic and reconstructive surgery,

G M Bleeker

[Histopathological studies of extraocular muscles in dysthyroid ophthalmopathy].

April 1982, Rinsho shinkeigaku = Clinical neurology,

G M Bleeker

Medial entropion following orbital decompression for dysthyroid ophthalmopathy.

January 1988, Ophthalmic plastic and reconstructive surgery,