-transparent.png){kind=logo}
The distribution of type I collagen in normal and diseased renal tissues was studied using immunofluorescence and immunoelectron microscopy, and was compared with that of type III collagen. In normal human kidneys, a monoclonal antibody against type I or type III collagen reacted with the renal interstitium, but not with the intra-glomerular structures. In various types of glomerulonephritis, immunofluorescent staining for type I collagen was positive in the fibrocellular and fibrous crescents, sclerosed glomeruli, and infrequently within the glomerular mesangium. In the crescents and sclerosed glomeruli, type I collagen was co-localized with type III collagen. The staining intensity of type I collagen in those areas was generally stronger than that in the interstitium. Mesangial staining for type I collagen was present within the glomeruli, particularly with a marked mesangial matrix increase, but was less in amount and frequency compared with type III collagen staining. These findings indicate that the fibrosclerotic process in damaged glomeruli is accompanied by the appearance of interstitial collagens, and that participation of type I collagen is prominent in crescent organization and global glomerular sclerosis, but is less frequent in mesangial expansion, compared with type III collagen.
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
January 1978,
Zeitschrift fur Rheumatologie,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
October 1987,
The British journal of dermatology,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
May 1996,
The Histochemical journal,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
March 2024,
Journal of burn care & research : official publication of the American Burn Association,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
February 1991,
Matrix (Stuttgart, Germany),
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
December 1997,
Journal of glaucoma,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
January 1986,
Clinical physiology and biochemistry,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
February 1994,
Biochemical Society transactions,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
April 1996,
Journal of gastroenterology,
K Yoshioka, and
M Tohda, and
T Takemura, and
N Akano, and
K Matsubara, and
A Ooshima, and
S Maki
December 1980,
Pathology, research and practice,
