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The content of type I and III collagen in normal human skin from subjects of different ages was studied by means of a new high performance liquid chromatography method and by SDS-polyacrylamide gel electrophoresis and scanning electron microscopy. The ratio of types I and III collagen in covered skin remained constant throughout childhood and young adult life and the proportion of type III was shown to be the same as previously reported. However, in the elderly, the proportion of type III collagen in the dermis increased to a variable degree. Scanning electron microscopic examination showed a decrease in the number of collagen fibre bundles with age. Average bundle width varied significantly with age. These results may reflect an impaired synthesis of type I collagen in aged skin.
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
February 2008,
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
October 1990,
The Journal of pathology,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
September 1983,
The Journal of pathology,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
September 1985,
Collagen and related research,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
December 1989,
The Journal of dermatology,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
January 1990,
Annals of the New York Academy of Sciences,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
January 2015,
International journal of clinical and experimental medicine,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
May 1994,
The Histochemical journal,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
August 1980,
The Journal of investigative dermatology,
C R Lovell, and
K A Smolenski, and
V C Duance, and
N D Light, and
S Young, and
M Dyson
January 1980,
The Journal of pathology,
