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Forty-six coded chemicals were tested for their ability to induce sister chromatid exchanges (SCEs) and chromosomal aberrations (ABs) in cultured Chinese hamster ovary (CHO) cells using a standard protocol with and without exogenous metabolic activation. Sixteen chemicals were negative and 15 were positive in both assays; 15 were positive for SCEs only (one chemical that was positive for SCEs was equivocal for ABs), and no chemicals induced ABs only. The effect of cell harvest time on the ability to detect the induction of ABs was examined for 18 chemicals. Seven chemicals produced a positive response using both standard and extended harvest times, five were positive only using an extended harvest time, and six were negative using both harvest times. The relationship between cell cycle delay and SCE induction was also examined, and the two appear to be unrelated.
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
January 1989,
Environmental and molecular mutagenesis,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
January 1989,
Environmental and molecular mutagenesis,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
January 1987,
Environmental and molecular mutagenesis,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
December 1987,
Zhonghua ya yi xue hui za zhi,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
December 1980,
Mutation research,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
June 1977,
Journal of the National Cancer Institute,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
July 1992,
Mutagenesis,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
January 2001,
Teratogenesis, carcinogenesis, and mutagenesis,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
January 1979,
Acta biologica Academiae Scientiarum Hungaricae,
K S Loveday, and
B E Anderson, and
M A Resnick, and
E Zeiger
September 1993,
Mutagenesis,
