BIOMAT Database Logo BIOMAT Database Logo

[Effect of aging and physical inactivity on glucose tolerance and insulin sensitivity]. 1990

Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Research Center of Health, Physical Fitness and Sports, Nagoya University.

It has been well documented that glucose intolerance is associated with aging, but it is not yet clear whether this phenomenon is due to the aging process itself or is secondary to the appearance of other age-related conditions among which physical inactivity is one of most important variables. To evaluate the effect of aging process and/or physical inactivity on insulin action, this study was undertaken using the euglycemic insulin clamp technique and the oral glucose tolerance test (OGTT). Subjects without diabetes mellitus and other serious diseases consisted of 14 non-obese aged individuals and 10 young controls (YC group), ranging in age from 63 to 85 yrs, and from 19 to 21 yrs, respectively. The aged individuals were further divided into two groups (one was termed as the AS group, in which 7 aged subjects had been confined to bed for at least 3 months and the other was termed as the AC group in which 7 aged controls kept their daily physical activity such as walking). The results of OGTT did not show any remarkable differences between AC and YC groups. In the AS group, however, glucose intolerance and low insulin response during OGTT were observed. In view of the tissue insulin action, MCR, which is thought as a reliable marker for tissue insulin action, evaluated by euglycemic insulin clamp was 5.31 +/- 0.68, 8.57 +/- 1.20, 9.60 +/- 0.35 ml/kg/min in the AS, AC and YC groups, respectively (AS less than AC, p less than 0.05, AS less than YC, p less than 0.01, AC less than YCM, N.S.).(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D005260 Female Females
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D005951 Glucose Tolerance Test A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg). Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of interferon on glucose tolerance and insulin sensitivity.
May 1989, Diabetes,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of 10 days of physical inactivity on glucose tolerance in master athletes.
May 1990, Journal of applied physiology (Bethesda, Md. : 1985),
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
[Effect of prolonged physical inactivity on carbohydrate tolerance].
November 1969, Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging.
June 1990, The American journal of physiology,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.
January 2011, Bulletin of experimental biology and medicine,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs.
April 2012, American journal of veterinary research,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Glucose tolerance and insulin sensitivity.
April 1960, Diseases of the nervous system,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Glucose tolerance and insulin sensitivity.
August 1969, Clinical science,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men.
January 2003, Medicine and science in sports and exercise,
Y Sato, and K Yamanouchi, and H Nakajima, and T Shinozaki, and S Fujii, and N Chikada, and Y Suzuki, and K Chikada, and K Kato, and Y Oshida
Effect of a ketoacid diet on glucose tolerance and tissue insulin sensitivity.
November 1989, Kidney international. Supplement,
Copied contents to your clipboard!