BIOMAT Database Logo BIOMAT Database Logo

Effect of a ketoacid diet on glucose tolerance and tissue insulin sensitivity. 1989

M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Maladies Medicales des Reins, Transplantation Renale, Bordeaux, France.

Effects of a low protein (0.3 g/kg/day) diet on glucose tolerance and tissue insulin sensitivity were studied in 25 non-diabetic and eight insulin-dependent diabetic uremic patients before and three months after dietary treatment. Carbohydrates accounted for 65% of the caloric intake in the first group and 57% in the second. In the first group, a 50 g oral glucose tolerance test showed that after three months blood glucose was significantly reduced at T60 (P less than 0.05) and serum insulin at T0, T30 (P less than 0.05) and T60 (P less than 0.02). Ten patients of the first group underwent an euglycemic, hyperinsulinemic clamp study; the tissue sensitivity to insulin index of all three clamp periods improved (P less than 0.01 for the first and second, P less than 0.02 for the third). Five patients in the second group underwent a euglycemic clamp study; glucose metabolism increased with each clamp period. Concomitantly, their daily insulin requirements decreased from 37.2 +/- 3.1 to 24.8 +/- 2.7 U/day (P less than 0.05). This conspicuous improvement observed in both groups might be related to a decrease in uremic toxin(s) derived from protein intake. Beneficial results on atherosclerosis and cardiovascular pathology may occur from the reduction of hyperinsulinism.

UI MeSH Term Description Entries
D007333 Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. Insulin Sensitivity,Resistance, Insulin,Sensitivity, Insulin
D007651 Keto Acids Carboxylic acids that contain a KETONE group. Oxo Acids,Oxoacids,Acids, Keto,Acids, Oxo
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003922 Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. Diabetes Mellitus, Brittle,Diabetes Mellitus, Insulin-Dependent,Diabetes Mellitus, Juvenile-Onset,Diabetes Mellitus, Ketosis-Prone,Diabetes Mellitus, Sudden-Onset,Diabetes, Autoimmune,IDDM,Autoimmune Diabetes,Diabetes Mellitus, Insulin-Dependent, 1,Diabetes Mellitus, Type I,Insulin-Dependent Diabetes Mellitus 1,Juvenile-Onset Diabetes,Type 1 Diabetes,Type 1 Diabetes Mellitus,Brittle Diabetes Mellitus,Diabetes Mellitus, Insulin Dependent,Diabetes Mellitus, Juvenile Onset,Diabetes Mellitus, Ketosis Prone,Diabetes Mellitus, Sudden Onset,Diabetes, Juvenile-Onset,Diabetes, Type 1,Insulin Dependent Diabetes Mellitus 1,Insulin-Dependent Diabetes Mellitus,Juvenile Onset Diabetes,Juvenile-Onset Diabetes Mellitus,Ketosis-Prone Diabetes Mellitus,Sudden-Onset Diabetes Mellitus
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D005260 Female Females
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Effect of interferon on glucose tolerance and insulin sensitivity.
May 1989, Diabetes,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet.
July 2010, Endocrinology,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.
January 2011, Bulletin of experimental biology and medicine,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
November 2011, Endocrinology,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs.
April 2012, American journal of veterinary research,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Glucose tolerance and insulin sensitivity.
April 1960, Diseases of the nervous system,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Glucose tolerance and insulin sensitivity.
August 1969, Clinical science,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Effect of short-term consumption of a high fat diet on glucose tolerance and insulin sensitivity in the rat.
October 1987, Journal of nutritional science and vitaminology,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
[Effect of aging and physical inactivity on glucose tolerance and insulin sensitivity].
September 1990, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
M Aparicio, and H Gin, and L Potaux, and J L Bouchet, and D Morel, and J Aubertin
Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men.
January 2003, Medicine and science in sports and exercise,
Copied contents to your clipboard!