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Between 1971 and 1986 532 proximal gastric vagotomies were carried out at the Pelgulinna Hospital. The five-year recurrence rate was 5.5% (n = 29). We have studied 40 patients with chronic duodenal ulceration, 20 patients who had effective proximal gastric vagotomy, and seven patients who presented with recurrent ulcers after proximal gastric vagotomy. Patients who had positive Hollander tests after vagotomy, and those with disorders of gastric motility, were excluded. In the group with recurrent ulcers the concentration of neutral mucopolysaccharides in the gastric juice was significantly lower than in the other two groups, and it correlated with the amount of material showing a positive reaction to periodic acid Schiff (PAS) in the gastric mucosa. This group also had significantly higher mean serum gastrin concentrations and mast cell degranulation rates in the mucosa of the fundus and the antrum. We conclude that qualitative changes in the production of gastric mucus lead to defective functioning of the mucosal barrier in patients with recurrent ulcers and may be one of the causes of recurrences.
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
November 1983,
World journal of surgery,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
July 1994,
The British journal of surgery,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
January 1980,
Brain research bulletin,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
January 1981,
Scandinavian journal of gastroenterology,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
January 1980,
Chirurgisches Forum fur experimentelle und klinische Forschung,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
June 1988,
The British journal of surgery,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
April 1975,
The American surgeon,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
May 1980,
Nihon geka hokan. Archiv fur japanische Chirurgie,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
July 1983,
Surgery,
M Leibur, and
R Truve, and
U Sibul, and
P Roosaar, and
K Zilmer
May 1982,
Revista espanola de las enfermedades del aparato digestivo,
