Biomaterial Database

Breast cancer: oncogenes and suppressor genes. 1990

E Anderson, and T Howell

UI	MeSH Term	Description	Entries
D009857	Oncogenes	Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.	Transforming Genes,Oncogene,Transforming Gene,Gene, Transforming,Genes, Transforming
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005784	Gene Amplification	A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.	Amplification, Gene
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016153	Genes, Suppressor	Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.	Amber Suppressor Genes,Frameshift Suppressor Genes,Genes, Amber Suppressor,Genes, Frameshift Suppressor,Genes, Nonsense Mutation Suppressor,Genes, Ochre Suppressor,Genes, Second-Site Suppressor,Nonsense Mutation Suppressor Genes,Ochre Suppressor Genes,Second-Site Suppressor Genes,Genes, Opal Suppressor,Suppressor Genes,Amber Suppressor Gene,Frameshift Suppressor Gene,Gene, Amber Suppressor,Gene, Frameshift Suppressor,Gene, Ochre Suppressor,Gene, Opal Suppressor,Gene, Second-Site Suppressor,Gene, Suppressor,Genes, Second Site Suppressor,Ochre Suppressor Gene,Opal Suppressor Gene,Opal Suppressor Genes,Second Site Suppressor Genes,Second-Site Suppressor Gene,Suppressor Gene,Suppressor Gene, Amber,Suppressor Gene, Frameshift,Suppressor Gene, Ochre,Suppressor Gene, Opal,Suppressor Gene, Second-Site,Suppressor Genes, Amber,Suppressor Genes, Frameshift,Suppressor Genes, Ochre,Suppressor Genes, Opal,Suppressor Genes, Second-Site