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Oncogenes (c-erbB-2, c-myc, and some genes linked to the 11q13 lesion), tumor suppressor genes (retinoblastoma gene, p53) and an antimetastatic gene (nm23/nucleoside diphosphate kinase) play important roles in breast cancer progression. Amplification of c-erbB-2, c-myc, and int-2, and expression of RB, p53(mutant), and NDP kinase were determined in 77 primary breast cancer specimens. nm23-H1 allelic loss was also studied. c-erbB-2 and c-myc amplification, loss of RB expression, p53(mutant) expression, and nm23-H1 allelic loss were also found in non-invasive carcinoma. int-2 amplification was significantly correlated with lymph node status (P = 0.02) and a significant association was found between p53(mutant) expression and tumor size (P = 0.04). c-erbB-2 amplification was strongly associated with disease-free and overall survival in multivariate analysis (P = 0.002). All of the c-erbB-2 amplified cases and all but one of the int-2 amplified cases in node-positive patients had relapsed within 2 years post resection. The cancer cells may acquire new proliferative pathways sequentially as a result of multiple genetic alterations which enable them to bypass the estrogen-dependent proliferation.
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
February 1993,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
July 1990,
Annals of oncology : official journal of the European Society for Medical Oncology,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
September 1993,
Presse medicale (Paris, France : 1983),
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
February 1993,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
January 1992,
Cancer treatment and research,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
January 2001,
Epidemiologic reviews,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
January 1993,
British journal of hospital medicine,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
March 2019,
Genes & diseases,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
April 2011,
Nihon rinsho. Japanese journal of clinical medicine,
H Yamashita, and
S Kobayashi, and
H Iwase, and
Y Itoh, and
T Kuzushima, and
H Iwata, and
K Itoh, and
A Naito, and
T Yamashita, and
A Masaoka
January 1994,
CA: a cancer journal for clinicians,
