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The effect of phorbol esters on the transport of amino acids has been evaluated in cultured human fibroblasts. The activity of the Na(+)-dependent system XAG- for anionic amino acids is selectively and markedly stimulated by phorbol esters. The effect is maximal within 15 min; it is attributable to an increase in transport maximum (Vmax) and not prevented by inhibitors of protein synthesis. The half-maximal stimulation is observed at concentrations of phorbol 12,13-dibutyrate lower than 100 nM. Prolonged incubations in the presence of 1 microM phorbol 12,13-dibutyrate lower the binding of the ligand to its receptor with a loss of the stimulatory effect on transport. The results presented indicate that the stimulation of amino acid transport through system XAG- by phorbol esters requires the activation of protein kinase C.
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O Bussolati, and
R Visigalli, and
B M Rotoli, and
P A Rossi, and
G G Guidotti, and
G C Gazzola
February 1980,
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R Franchi-Gazzola, and
O Bussolati, and
R Visigalli, and
B M Rotoli, and
P A Rossi, and
G G Guidotti, and
G C Gazzola
February 1992,
Biochimica et biophysica acta,
R Franchi-Gazzola, and
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G G Guidotti, and
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May 1986,
The American journal of physiology,
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January 1986,
FEBS letters,
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April 1985,
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October 1982,
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R Franchi-Gazzola, and
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January 1993,
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January 1982,
Carcinogenesis; a comprehensive survey,
R Franchi-Gazzola, and
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G C Gazzola
November 1974,
Biochimica et biophysica acta,
R Franchi-Gazzola, and
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April 1986,
Biochemical and biophysical research communications,
